Best Actor - Lex Luthor, All-Star Superman #12
That is a sneer to end all sneers. The low angle perfectly captures the fact that given super-powers, Lex is exactly what he always accused Superman of being; a selfish overlord with no respect for the people below him. Delicious.
Also there's this, my all time favorite kind of panel. That would be the "Bus Smashes Into Superhero Panel", seen on previous Panel Discussions here and here. Bonus points for showing the driver flying out of the car, which is certainly what would really happen.
Vampires get it in the face, Penguin gets it twixt the legs, and Superman just doesn't get it, after the jump...
Most Unpleasant Panel - Batman and the Outsiders #11
That's The Penguin down there, if you can't tell. This looks like an illustration from a fan art no one, and I mean NO one wants to see.
Best Interrogation Technique - Criminal Macabre - Cell Block 666 #1
Man, I love when heroes don't let the villains deliver their big speeches. Some bonuses include the subtle "click click" sound effect of the hammer clicking in the first panel, and the vampire's hilarious self-absorbed posturing as he's about to launch into his speech. Not today, sucka!
The Magic of Comics - DC Universe: Decisions #1
Just a small example of the between the panel magic of sequential art. Wonderful clean work here, from the rustle of the newspaper to the air brushing through Lois's hair. And judging from her expression, Superman is definitely not getting laid tonight. What a nerd.